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10 20 30 40 50 60
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN ------------------------------------------------------------
ATF7_HUMAN ------------------------------------------------------------
CREB5_HUMAN ------------------------------------------------------------
ATF6A_HUMAN ------------------------------------------------------------
ATF6B_HUMAN ------------------------------------------------------------
BACH1_HUMAN -----MSLSE---NSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTI-FVEGQRFRAH-RS
BACH2_HUMAN -----MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTL-IVERKEFRAH-RA
NF2L1_HUMAN MLSLKKYLTEG--LLQFTILLSLIGVRVDVDTYLTSQLPPLREIIL----GP-SSAYTQT
NF2L3_HUMAN MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALS
NF2L2_HUMAN ------------------------------------------------------------
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. M22LKMSLSEG22LL4FTY22S2HGT2V2LDL22QRKK24LCDVTLLFVEGP322A22RS
70 80 90 100 110 120
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN ------------------------------------------------------------
ATF7_HUMAN ------------------------------------------------------------
CREB5_HUMAN ------------------------------------------------------------
ATF6A_HUMAN ----------------------------------------------MGEPAGVAGTMESP
ATF6B_HUMAN ----------------------------------------------MAELMLLSEIADPT
BACH1_HUMAN VLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCV
BACH2_HUMAN VLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCA
NF2L1_HUMAN QFHNLRNTLDGYGIHPKSIDLDNYFTAR-RLLSQVRALDRFQVPTTEVNAWLVHRDPEGS
NF2L3_HUMAN PFSASGGWGRAGHLHPKGRELDPAAPPEGQLLREVRALGVPFVPRTSVDAWLVHSVAAGS
NF2L2_HUMAN ------------------------------------------------------------
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. V2AACS4YF4444V22K442LD44LPEEVTLLGFV22LQFAY22K2M22A2LVHEVAE2S
130 140 150 160 170 180
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN ------------------------------------------------------------
ATF7_HUMAN ------------------------------------------------------------
CREB5_HUMAN ------------------------------------------------------------
ATF6A_HUMAN FSPGLFHRLDEDW---DSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWES
ATF6B_HUMAN RFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEP
BACH1_HUMAN EFLSVHNIEESCFQFLKFKFLDSTADQQEC--------PRKKCFSSHCQKTDLKLSLLDQ
BACH2_HUMAN EFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDS
NF2L1_HUMAN VSGSQPNSGLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDI
NF2L3_HUMAN ADEAHGLLGAAAASSTGGAGAS-VDGG---SQAVQGGGGDPR--AARSGP----------
NF2L2_HUMAN -------------------------------------------MMDLELPPPGLPSQQDM
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. EFLS6HNL2D322S2LGS2LLS2LDGG5E2SE55QG5G2D66CFN27SLPVD2DLSP6DS
190 200 210 220 230 240
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN ------------------------------------------------------------
ATF7_HUMAN ------------------------------------------------------------
CREB5_HUMAN ------------------------------------------------------------
ATF6A_HUMAN DIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDS---------YSSTQHVPEELD
ATF6B_HUMAN P-WELL-PIFPDLQVKSEPSSPCSSSSLSSESSRLSTEP---------SSEALGVGEVLH
BACH1_HUMAN --------RDLETDEVEEF-------LENKNVQTPQCKLRR------YQGNAKASPPL-Q
BACH2_HUMAN ETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPT------DTKESSEKDALTQ
NF2L1_HUMAN DLIDILWRQDIDLGAGREVFDYSHRQKEQDVEKELR-DGGEQDTWAGEGAEALARNLLVD
NF2L3_HUMAN ------------LDAGEE------EKAPAEPTAQVP-DAG--------GCASEENGVLRE
NF2L2_HUMAN DLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLD
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. DL2DILW23DIDLD322E3FD5S5RS3EYE222Q2S5D7GRQ22222E2SEAL2V22LLD
250 260 270 280 290 300
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN -----------------------------------------------------------M
ATF7_HUMAN -----------------------------------------------------------M
CREB5_HUMAN --------------------------------------------------MIYEESKMNL
ATF6A_HUMAN LSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQ-VNSKPSI--
ATF6B_HUMAN VKTESLAPPLCLLGDDPTSSFETVQINVI-PTSDDSSDVQTKIEPVSPCSSVNSEASLLS
BACH1_HUMAN DSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTG--ESSVKDIHASVQPNER
BACH2_HUMAN YPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEE
NF2L1_HUMAN GETGESFPAQVPSGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPA
NF2L3_HUMAN KHEAVDHSSQHEENEERVSAQKENSLQ---------QNDD---DENKIAEKPDWEAEKTT
NF2L2_HUMAN EETGEFLPIQPAQHIQSETSGSANYSQV--AHIPKSDALYFDDCMQLLAQTFPFVDDNEV
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. 72T227YP2QCLEGEDSTS2SS32PLQV5F2T6P6S2N2E2GLD2SSI237VPSE22NEM
310 320 330 340 350 360
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN ------------------------------------------------------------
ATF2_HUMAN SDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNC
ATF7_HUMAN GDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNC
CREB5_HUMAN EQERPSVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNML-SDQTPTPTRFLKNC
ATF6A_HUMAN ---Q---------PKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAP
ATF6B_HUMAN ADSS---------SQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSS
BACH1_HUMAN SENECLG------G-VPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTP---
BACH2_HUMAN SITLCLS------GDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCL
NF2L1_HUMAN LQNNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLSTNYSL
NF2L3_HUMAN ESRN--ERHLNGTDTSFSLEDLFQLLSSQPENSLEGISLGDIPLPGSISDGMNSSAHYHV
NF2L2_HUMAN SSATFQSLV---PDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELL
NFE2_HUMAN ------------------------------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. SD22PLSC6APGCGQ2F2LEDHL2V22HKHEMTLKFP22TA222LG2DQTPTPTSFLKN2
370 380 390 400 410 420
| | | | | |
AP1_HUMAN --------------------------------------------MTAKMETTFYDDALNA
JUND_HUMAN ------------------METPFYGDEALSGLGGGASGSGGTFASPGRLFPGAPPTAAAG
JUNB_HUMAN --------------MCTKMEQPFYHDDSYTATGYGRAPGG---------------LSLHD
MAFB_HUMAN --------------MAAELSMG-PELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRP
MAF_HUMAN --------------MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPV-ETDRIISQ
ATF2_HUMAN EEVGLFNELASPFENEFKKASEDDIKKM--------------P--LDLSPLATPIIRSKI
ATF7_HUMAN EEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGP--LDMSLPSTPDIKIKE
CREB5_HUMAN EEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNV
ATF6A_HUMAN TKG----QTVLLSQP---TVVQLQAPGVLPSAQPVLAVAG-----GVTQLPNHVVNVVP-
ATF6B_HUMAN GKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPE
BACH1_HUMAN ---FPHNSSIDPHGLYSLSLLH-------TYDQ---YGDLN-----FAGMQNTTVLTEKP
BACH2_HUMAN RSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKE
NF2L1_HUMAN APNTPINQNVSLHQASLGGCSQDFLLFSPEVESLPVASSSTLLPLAPSNSTSLNSTFGST
NF2L3_HUMAN NFSQAISQDVNLHEAILL-CPNNTFRRDPTARTSQ--SQEPFLQLN-SHTTNPEQTLPGT
NF2L2_HUMAN SIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFED
NFE2_HUMAN -----------------------------MSPCPPQQSRNRVIQLSTSELGEMELTWQEI
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ----------MTMES-GAENQQSGDAAVTEAENQQMTVQA-QPQIATLAQVSMPAAHATS
CREM_HUMAN ----------MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRR
CEBPA_HUMAN --------------------MESADFYEAEPRPPMSS-HLQSPPHAPSSAAFGFPRGAGP
CEBPB_HUMAN --------------MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAP
CEBPE_HUMAN -----------------------------------------------MSHGTYYECEPRG
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN -----------------------------------MARPVSDRTPAPLLLGGPAGTPPGG
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------MSDAGG
ATF4_HUMAN -------------------------------MTEMSFLSSEVLVGDLMSPFDPSGLGAEE
ATF5_HUMAN ----------------------------------------MSLLATLGLELDRALLPAS-
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------------
FOSB_HUMAN ------------------------------------------------------------
FOSL2_HUMAN ------------------------------------------------------------
FOS_HUMAN ------------------------------------------------------------
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. EEVGL2N2LVSLHEM22L2AQPS22L23PPS3T36V2SS36SP2LAPLSL622PGTGA23
430 440 450 460 470 480
| | | | | |
AP1_HUMAN SFLPSESGPYGYSNP--KILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASP
JUND_HUMAN SMMKKDALTLSLSEQVAAALKPAPAPASYPPAADGAPSA-APPDGLLASPDLGLLKLASP
JUNB_HUMAN YKLLKPSLAVNLADPY-RSLKAPGARGPGPEGGGGGSYFSGQGSDTGAS-----LKLASS
MAFB_HUMAN CTRLQPAGSVSSTPLSTPCSSVPSSPSFSP------TEQKTHLEDLYWM--ASNYQQMNP
MAF_HUMAN CGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWM--TGYPQQLNP
ATF2_HUMAN EEPSVVETTHQDSPLPHPESTTSDEKEVP--LAQT--AQPTSAIVRPASLQ--VPNVLLT
ATF7_HUMAN EEPVEVDSSPPDSPASSPCSPPLKEKEVT--PKPVLISTPTPTIVRPGSLP------LHL
CREB5_HUMAN VIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMP
ATF6A_HUMAN APSANSPVNGKLSVTKPVLQSTMRNVG-----SDIAVLRRQQRMIKNRESACQSRKKKKE
ATF6B_HUMAN GPAPSLPRPERKSIVPAPMPGNSCPPE-----VDAKLLKRQQRMIKNRESACQSRRKKKE
BACH1_HUMAN LSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDR--------------SSVEREVAEH
BACH2_HUMAN VSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEP
NF2L1_HUMAN NLTGLFFPPQLNGTA--NDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQL
NF2L3_HUMAN NLTG-FLSPVDNHMR--NLTSQDLLYD-----LDINIFDEINLMSLATEDNFDPIDVSQL
NF2L2_HUMAN SFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSEL
NFE2_HUMAN MSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSH
ATF1_HUMAN -----------MEDSHKSTTSETAPQPGSAVQGAHISHIAQ------------QVSSLSE
CREB1_HUMAN SAPTVTLVQLPNGQTVQVHGVIQAAQP-SVIQSPQVQTVQSSCKDLKRLFSGTQISTIAE
CREM_HUMAN GSPAVTLVQLPSGQTIHVQGVIQTPQP-WVIQSSEIHTVQ--------------VAAIAE
CEBPA_HUMAN AQPPAPPAAPEP----LGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAV
CEBPB_HUMAN AAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAP
CEBPE_HUMAN GQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIE--SGEEQLLSDLF-----AVKPAPEA
CEBPD_HUMAN ---------------------------------------------------MSAALFSLD
DBP_HUMAN GALLGLRSLLQGTSKPKEPASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGG
HLF_HUMAN -----MEK--MSRPLPLNPTFIPPPYGVLRS--LLENPLKLPLHHEDAFSKDKDKEKKLD
TEF_HUMAN GKKPPVDP--QAGPGP-GPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEE
ATF4_HUMAN SLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKM
ATF5_HUMAN GLGWLVDYGKLPP--APAPLAPYEVLGGALE----GGLPVGGEPLAGDGFS--DWMTERV
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN ------------------------------------------------------MELELD
FOSB_HUMAN -------------------------------------------------------MFQAF
FOSL2_HUMAN -------------------------------------------------------MYQDY
FOS_HUMAN ------------------------------------------------------MMFSGF
FOSL1_HUMAN ------------------------------------------------------------
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. G2PPLV2SPL3SSP2PLPPSS2PEAPGDSSP4SD3ASLQE3SL2DLAAS2SG422MLS3P
490 500 510 520 530 540
| | | | | |
AP1_HUMAN ELERLIIQSSNGHITTTPTPT-QFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSA
JUND_HUMAN ELERLIIQS-NGLVTTTPTSS-QFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGRAA
JUNB_HUMAN ELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDD
MAFB_HUMAN EALNLTPEDAVEALIG-SHPVPQPLQSF-----------DSFRGAHHHHHHHHPHPHHAY
MAF_HUMAN EALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAV
ATF2_HUMAN SSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITS
ATF7_HUMAN GYDP---LHPTLPSPTS--VITQAPPSNRQMGSPTGSLPLVMHLANGQTMPV-----LPG
CREB5_HUMAN GSSAVLMPMERQMSVNSSIMGIEGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSN
ATF6A_HUMAN YMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFII
ATF6B_HUMAN YLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIA
BACH1_HUMAN LAKGFW-SDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTT
BACH2_HUMAN VPKGLW-VGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTS
NF2L1_HUMAN EEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSD
NF2L3_HUMAN FDEPDSDSGLSLDSSHNNTSV-------------------IKSNSSHSVCDEGAIGYCTD
NF2L2_HUMAN LNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLG
NFE2_HUMAN VPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLN
ATF1_HUMAN SEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDT---RGRKGDGENSGVSAAVTS
CREB1_HUMAN SEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITT
CREM_HUMAN TDESAES-EGVIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIAT
CEBPA_HUMAN GPTGGGGGGDFDYPGAPAGPGGAVMPGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPAL
CEBPB_HUMAN APASSGQHHDFLSDLFSDDYGGKNCK-----KPAEYGYVSLGRLGAAKGALHPGCFAPLH
CEBPE_HUMAN RGLKGPGTPAFPHYLPPDPRPFAY-------PPHTFG-----------------------
CEBPD_HUMAN GPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMA
DBP_HUMAN SPRGRPGPVPAPGLLAPLLWERTLPFG----DVEYVDLDAFLLEHGLPPSPPPPGGPSPE
HLF_HUMAN DESNSP-TVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHD--HSP
TEF_HUMAN DEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLA--HNL
ATF4_HUMAN DLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLT
ATF5_HUMAN DFT-----ALLPLEP--PLPPGTLPQPSPTPPDLEAMASLLKKELEQMEDFFLDAP--LL
NRL_HUMAN ------------------------------MALPPSPLAMEYVNDFDLMKFEVKREPSEG
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN ------------------------------------------------------------
ATF3_HUMAN ------------------------------------------------------------
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN AGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNI
FOSB_HUMAN PGDYD-SG----SRCSSSPSAE---SQYLSSVDSFGSPPTAAASQE-CAGLGEMPGSF--
FOSL2_HUMAN PGNFD-TS----SRGSSGSPAH---------AESYSSGGG--GQQKFRVDMPGSGSAF--
FOS_HUMAN NADYEASS----SRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF--
FOSL1_HUMAN -----------------------MFRDFGEPGPSSGNGGGYGGPAQPPAAAQAAQQKFHL
XBP1_HUMAN ------------------------------------------------------------
Consensus
Prim.cons. EP2GLESSD2V2SSLSSP2PLGQ2PS4R5S2ALSSSDAPG2VRS2E23VSPEGAP3AFT3
550 560 570 580 590 600
| | | | | |
AP1_HUMAN AQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAA
JUND_HUMAN AAAAAAAG--GPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGG------AA
JUNB_HUMAN LHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTG
MAFB_HUMAN PGAGVA----HDELGPHAHPHHHH----HHQASPPPSSAASPAQQLPTSHPGPGPHATAS
MAF_HUMAN VSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPAS
ATF2_HUMAN SNVH-VPAAVPLVRPVTMVPSVPGIPGPS---------SPQPVQSEAKMRLKAALTQQHP
ATF7_HUMAN PPVQ-MPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVS
CREB5_HUMAN GNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQ
ATF6A_HUMAN LNYGPMSMLEQDSRRMNPSVSPANQ--RRHLLGFSAKEA-------QDTSDGIIQKNSYR
ATF6B_HUMAN FNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSP
BACH1_HUMAN LSSVNCPF--------------ISTLSTEGCSSNLE-----------IGNDDYVSEPQQE
BACH2_HUMAN SSCSSYSYAEDGSGG-SPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQI
NF2L1_HUMAN SETLDLEEAEGAVG-YQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSAD
NF2L3_HUMAN HESSSHHDLEGAVGGYYPEPSKLCHLDQSDSDFHGDLTF-QHVFHNHTYHLQPTAPESTS
NF2L2_HUMAN LSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQST-HVHDAQCENT-PEKEL
NFE2_HUMAN YSDAESLELEGTEAG----------RRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAET
ATF1_HUMAN MSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYA-Q
CREB1_HUMAN VTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYA-Q
CREM_HUMAN MAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQ
CEBPA_HUMAN RPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQ
CEBPB_HUMAN PPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRA-YLGYQAVPSGS
CEBPE_HUMAN -PDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPL-----QYQVAHCGQ
CEBPD_HUMAN AVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGD
DBP_HUMAN PSPARTPAPSPGPGSCGSASPRSSPGHAPARAALGTASGHRAG---LT--SRDTPSPVDP
HLF_HUMAN HPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPA--NRNTPSPIDP
TEF_HUMAN LLPVAELEGKESASSSTASPPSSST---AIFQPSETVSSTESS--LEK--ERETPSPIDP
ATF4_HUMAN KPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIK
ATF5_HUMAN PPPSPPPLP-PPPLPPAPSLPLSLP--SFDLPQPPVLDTLD-----------LLAIYCRN
NRL_HUMAN RPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGL
DDIT3_HUMAN ---------------------------MAAESLPFSFGTLSSWELEAWYEDLQEVLSS--
ZHANG_HUMAN -------MEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHLDPGLSSPGPLSSSGG
ATF3_HUMAN -------------------------------------------MMLQHPGQVSASEVSAS
BATF_HUMAN ------------------------------------------------------------
CEBPG_HUMAN ------------------------------------------------------------
MAFF_HUMAN ------------------------------------------------------------
MAFG_HUMAN ------------------------------------------------------------
MAFK_HUMAN ------------------------------------------------------------
CREB3_HUMAN LSSSNPCLVHHDHTYSLPRETVSMDLGECEISLTGRTGFMGLAIHTFPFAESESCRKEGT
FOSB_HUMAN VPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDP-----YDMPGTSYSTPGM
FOSL2_HUMAN IPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLA-----SVPGHMALPRPGV
FOS_HUMAN IPTVTAISTSPDLQWLVQPALVSSVAPSQTRA----PHPFGV-----PAPSAGAYSRAGV
FOSL1_HUMAN VPSINTMSGSQELQWMVQPHFLGPSSYPRPLTYPQYSPPQPR-----PGVIRALGPPPGV
XBP1_HUMAN ---------------MVVVAAAPNPADGTPKVLLLSGQPASAA----GAPAGQALPLMVP
Consensus
Prim.cons. LPPV2APEPE2D2232VPSPP2SSP2SSPGLSGPS4P2PL224N2LAT23GGA2LPPSG3
610 620 630 640 650 660
| | | | | |
AP1_HUMAN GLAFPAQPQQQQQ--PPHHLPQQMPVQHPR-L-QALKEEPQTV--PEMP--GETPPLS--
JUND_HUMAN TVAFAAEPVPFPP--PP----PPGALGPPR-L-AALKDEPQTV--PDVPSFGESPPLS--
JUNB_HUMAN S-SYPTTTISYLPHAPPFAGGHPAQLGLGRGA-STFKEEPQTV--PEARSRDATPPVS--
MAFB_HUMAN ATAAGGNGS------------------------VEDRFSDDQL--VSMSVRELNRHLR--
MAF_HUMAN AGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQL--VTMSVRELNRQLR--
ATF2_HUMAN PVTNG-DTVKGHGSGLVRTQSEE-SRPQSLQQPATSTTETPAS--PAHTTPQTQSTSGRR
ATF7_HUMAN SINGGCGMVVGTASTMVTARPEQ-SQILIQHPDAPSPAQPQVS--PAQPTP---STGGRR
CREB5_HUMAN NHPHHHSHSHLHAHPAHHQTSPH-PPLHTGNQAQVSPATQQMQ--PTQTIQPPQPTGGRR
ATF6A_HUMAN YDH-SVSNDKALMVLTEEPLL----YIPPPPCQPLINTTESLR--LN---HELRGWVHRH
ATF6B_HUMAN TDQPSFSNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTESLR--LA---DELSGWVQRH
BACH1_HUMAN PCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRI--ISLSRNDFQSLLKMH
BACH2_HUMAN KCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQI--TDLPRNDFQMMIKMH
NF2L1_HUMAN LPPPSALKKGS-KEKQADFLDKQMSRDEHRARAMKIPFTNDKI--INLPVEEFNELLSKY
NF2L3_HUMAN EPFPWPGKSQKIRSRYLEDTDRNLSRDEQRAKALHIPFSVDEI--VGMPVDSFNSMLSRY
NF2L2_HUMAN PVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKI--INLPVVDFNEMMSKE
NFE2_HUMAN PL--ALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKI--VNLPVDDFNELLARY
ATF1_HUMAN TSDG-QQILVPSNQVVVQTASGDMQTYQIR------TTPSATS--LPQTVVMTSPVTLTS
CREB1_HUMAN TTDG-QQILVPSNQVVVQAASGDVQTYQIR------TAPTSTI--APGVVMASSPAL---
CREM_HUMAN SADGTQQFFVPGSQVVVQAATGDMPTYQIR-------APTAAL--PQGVVMAASPGSLHS
CEBPA_HUMAN TTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGA--AHPDLRASGGTGAGK
CEBPB_HUMAN SGSLSTSSSSSPPGTPSPADAKAP---------PTACYAGAAP--APSQVKS-------K
CEBPE_HUMAN TAMHLPPTLAAPGQPLRVLKAPLATAAP-----PCSPLLKAPS--PAGPLH--------K
CEBPD_HUMAN APGSLLPAQVGPCAQTVVSLAAAGQPTPPTSPEPPRSSPRQTP--APGPAREKS-----A
DBP_HUMAN DTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQP--IMKKAR--------K
HLF_HUMAN DTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQP--MIKKAR--------K
TEF_HUMAN NCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQP--MIKKAK--------K
ATF4_HUMAN EEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMV
ATF5_HUMAN E-------------AGQEEVGMPPLPPPQQPPPP-SPPQP------SRLAPYPHP-----
NRL_HUMAN SPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHVQLAERFSDAALVSMSVRELNRQLR
DDIT3_HUMAN -DENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSPHSPDSSQSSL
ZHANG_HUMAN GSDSGGLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGG
ATF3_HUMAN AIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSIT
BATF_HUMAN -------------------------------------------MPHSSDSSDSSFSRSPP
CEBPG_HUMAN -----MSKISQQNSTPGVNGISVIHTQAH-ASGLQQVPQLVPAGPGGGGKAVAPSKQSKK
MAFF_HUMAN MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLK
MAFG_HUMAN MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLK
MAFK_HUMAN MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLK
CREB3_HUMAN QMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKR
FOSB_HUMAN SGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEE-KRRVRRE-RNKL
FOSL2_HUMAN IKTI----GTTVG--------------------RRRRDEQLSPEEEE-KRRIRRE-RNKL
FOS_HUMAN VKTMTGGRAQSIG--------------------RRGKVEQLSPEEEE-KRRIRRE-RNKM
FOSL1_HUMAN ---------------------------------RRRPCEQISPEEEE-RRRVRRE-RNKL
XBP1_HUMAN AQRGASPEAASGG---------------LPQARKRQRLTHLSPEE----KALRRKLKNRV
Consensus
Prim.cons. 2TTPGG2NSSGPGS4PVEALGPPLS3DPPRALA2R2PFEPLTPEEPE2PVRDRSP3RS2K
670 680 690 700 710 720
| | | | | |
AP1_HUMAN PIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANML--
JUND_HUMAN PIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLL--
JUNB_HUMAN PINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLL--
MAFB_HUMAN GFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRL--
MAF_HUMAN GVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRL--
ATF2_HUMAN RRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLL--
ATF7_HUMAN RRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLL--
CREB5_HUMAN RRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSML--
ATF6A_HUMAN EVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYAS--
ATF6B_HUMAN QRGRRKIPQRAQERQKS-------QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHP--
BACH1_HUMAN KLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHI--
BACH2_HUMAN KLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQL--
NF2L1_HUMAN QLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEF--
NF2L3_HUMAN YLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDVCNLQAKKETLKREQAQC--
NF2L2_HUMAN QFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGEN--
NFE2_HUMAN PLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEA--
ATF1_HUMAN QTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTL--
CREB1_HUMAN PTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKAL--
CREM_HUMAN PQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETL--
CEBPA_HUMAN AKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQL--
CEBPB_HUMAN AKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQL--
CEBPE_HUMAN GKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQL--
CEBPD_HUMAN GKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQL--
DBP_HUMAN IQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAV--
HLF_HUMAN VFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL--
TEF_HUMAN VFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAEL--
ATF4_HUMAN AAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSL--
ATF5_HUMAN -ATTRG---DRKQKKRDQNKSAALRYRQRKRAEGEALEGECQGLEARNRELKERAESV--
NRL_HUMAN GCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARL--
DDIT3_HUMAN AQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERL--
ZHANG_HUMAN GGSGNDNNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENREL--
ATF3_HUMAN KAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEEL--
BATF_HUMAN PGKQDSSDDVRRVQRREKNRIAAQKSRQRQTQKADTLHLESEDLEKQNAALRKEIKQL--
CEBPG_HUMAN SSPMDRNSDEYR-QRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLL--
MAFF_HUMAN NRGYAASCRVKRVCQKEE----LQKQKSELEREVDKLARENAAMRLELDALRGKCEAL--
MAFG_HUMAN NRGYAASCRVKRVTQKEE----LEKQKAELQQEVEKLASENASMKLELDALRSKYEAL--
MAFK_HUMAN NRGYAASCRIKRVTQKEE----LERQRVELQQEVEKLARENSSMRLELDALRSKYEAL--
CREB3_HUMAN SAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISN
FOSB_HUMAN AAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEK-ERLEFVLVAHKPGCKIP-
FOSL2_HUMAN AAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEK-EKLEFMLVAHGPVCKI--
FOS_HUMAN AAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEK-EKLEFILAAHRPACKIPD
FOSL1_HUMAN AAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQK-ERLELVLEAHRPICKI--
XBP1_HUMAN AAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMD--
Consensus r n aa r l l n l l
Prim.cons. AATK2E2RRIKR2RRREKNRIAAQKCRKKKKEEIQELEKEVAELEAENEALRQEVE2LP2
730 740 750 760 770 780
| | | | | |
AP1_HUMAN ------------------------REQVAQLKQKVMNHVNSGCQLMLTQQLQTF------
JUND_HUMAN ------------------------REQVAQLKQKVLSHVNSGCQLLPQHQVPAY------
JUNB_HUMAN ------------------------REQVAQLKQKVMTHVSNGCQLLLGVKGHAF------
MAFB_HUMAN ------------------------ARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL
MAF_HUMAN ------------------------VRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFI
ATF2_HUMAN ------------------------RNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDS
ATF7_HUMAN ------------------------RNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKES
CREB5_HUMAN ------------------------KNEVAQLKQLLLTHKDCPITAMQKESQGYL-SPESS
ATF6A_HUMAN ------------------------PRSYQDFFEAIRRR-GDTFYVVSFRRDHLLLPATTH
ATF6B_HUMAN ------------------------DRSQPAFLDAIDRR-EDTFYVVSFRRDHLLLPAISH
BACH1_HUMAN ------------------------LSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYS
BACH2_HUMAN ------------------------KACMGELLDNFSCLSQEVCRDIQ-SPEQIQALHRYC
NF2L1_HUMAN ------------------------LRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYA
NF2L3_HUMAN ------------------------NKAINIMKQKLHDLYHDIFSRLRDDQGRPVNPNHYA
NF2L2_HUMAN ------------------------DKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYS
NFE2_HUMAN ------------------------DRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYA
ATF1_HUMAN ------------------------KDLYSNKSV---------------------------
CREB1_HUMAN ------------------------KDLYCHKSD---------------------------
CREM_HUMAN ------------------------KDICSPKTD---------------------------
CEBPA_HUMAN ------------------------SRELDTLRGIFRQLPESS-L-VKAMGNCA-------
CEBPB_HUMAN ------------------------SRELSTLRNLFKQLPEP--L-LASSGHC--------
CEBPE_HUMAN ------------------------TQELDTLRNLFRQIPEAANL-IKGVGGCS-------
CEBPD_HUMAN ------------------------TRDLAGLRQFFKQLPSPPFLPAAGTADCR-------
DBP_HUMAN ------------------------RQELSHYRAVLSRYQAQHGAL---------------
HLF_HUMAN ------------------------RKELGKCKNILAKYEARHGPL---------------
TEF_HUMAN ------------------------RKEVGKCKTIVSKYETKYGPL---------------
ATF4_HUMAN ------------------------AKEIQYLKDLIEEVRKARGKKRVP------------
ATF5_HUMAN ------------------------EREIQYVKDLLIEVYKARSQRTRSC-----------
NRL_HUMAN ------------------------ARERDLYKARCDRLTSSGPGSGDPSHLFL-------
DDIT3_HUMAN ------------------------TREVEATRR-ALIDR----MVNLHQA----------
ZHANG_HUMAN ------------------------GKRVQALQEESRYLR----AVLANETGLARLLSRLS
ATF3_HUMAN ------------------------KNEKQHLIYMLNLHRPTCIVRAQNGRTPED---ERN
BATF_HUMAN ------------------------TEELKYFTSVLNSHEPLCSVLAASTPSPPEVVYSAH
CEBPG_HUMAN ------------------------TKELSVLKDLFLEHAHNLADNVQSISTENTTADGDN
MAFF_HUMAN ------------------------QGFARSVAAARGPATLVAPASVITIVKSTPGSGSGP
MAFG_HUMAN ------------------------QTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSV
MAFK_HUMAN ------------------------QTFARTVARGPVAPSKVATTSVITIVKSTELSSTSV
CREB3_HUMAN K---------------------TSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGV
FOSB_HUMAN ---------------------------YEEGPGPG-------PLAEVRDLPGSAPAKEDG
FOSL2_HUMAN -----------------------SPEERRSPPAPGL-----QPMRSGGGSVGAVVVKQEP
FOS_HUMAN DLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEP
FOSL1_HUMAN ------------------------------------------PEGAKEGDTGSTSGTSSP
XBP1_HUMAN -----------------------ALVAEEEAEAKGN-----EVRPVAGSAESAALRLRAP
Consensus
Prim.cons. 2LGFPEEMSVASLDLTGGLPEV2SRRELAQLKQLLL5L2ESGF3LL2SSSGG3LSP4EYS
790 800 810 820 830 840
| | | | | |
AP1_HUMAN ------------------------------------------------------------
JUND_HUMAN ------------------------------------------------------------
JUNB_HUMAN ------------------------------------------------------------
MAFB_HUMAN ------------------------------------------------------------
MAF_HUMAN TEPTRKLEPSVGYATFWKPQHRVLTSVFTK------------------------------
ATF2_HUMAN SEDISVPSSPHTEAIQHSSVST-SNGVSSTSKAEAVATSV----LTQMADQSTE---PAL
ATF7_HUMAN SE----PTGSPAPVIQHSSATAPSNGLSVRSAAEAVATSV----LTQMASQRTELSMPIQ
CREB5_HUMAN PPASPVPACSQQQVIQHNTITT------SSSVSEVVGSST----LSQLTTHRTDLN-PIL
ATF6A_HUMAN NKTTRPKMSIVLPAININENVINGQ---DYEVMMQIDCQV----MDTRILHIKSSSVPPY
ATF6B_HUMAN NKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEV----MDTRVIHIKTSTVPPS
BACH1_HUMAN AADCPLSFLISEKDKSTPDG--ELALPSIFSLSDRPPAVL--------PPCARGNSEPGY
BACH2_HUMAN PVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENC
NF2L1_HUMAN LQYAGDGSVLLIPRTMADQQARRQERKPKDRRK---------------------------
NF2L3_HUMAN LQCTHDGSILIVPKELVASGHKKETQKGKRK-----------------------------
NF2L2_HUMAN LQQTRDGNVFLVPKSKKPDVKKN-------------------------------------
NFE2_HUMAN LQQAADGTIFLVPRGTKMEATD--------------------------------------
ATF1_HUMAN ------------------------------------------------------------
CREB1_HUMAN ------------------------------------------------------------
CREM_HUMAN ------------------------------------------------------------
CEBPA_HUMAN ------------------------------------------------------------
CEBPB_HUMAN ------------------------------------------------------------
CEBPE_HUMAN ------------------------------------------------------------
CEBPD_HUMAN ------------------------------------------------------------
DBP_HUMAN ------------------------------------------------------------
HLF_HUMAN ------------------------------------------------------------
TEF_HUMAN ------------------------------------------------------------
ATF4_HUMAN ------------------------------------------------------------
ATF5_HUMAN ------------------------------------------------------------
NRL_HUMAN ------------------------------------------------------------
DDIT3_HUMAN ------------------------------------------------------------
ZHANG_HUMAN GVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSA------GGVCLHVDKDKVSVE
ATF3_HUMAN LFIQ-QIKEGTLQS----------------------------------------------
BATF_HUMAN AFHQPHVSSPRFQP----------------------------------------------
CEBPG_HUMAN AGQ---------------------------------------------------------
MAFF_HUMAN AHGPDPAHGPASCS----------------------------------------------
MAFG_HUMAN ITIVKSKTDARS------------------------------------------------
MAFK_HUMAN PFSAAS------------------------------------------------------
CREB3_HUMAN LSR---QLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQA
FOSB_HUMAN FSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLG-----------DPFPVVNP--
FOSL2_HUMAN LEEDSPSSSSAGLDKAQRSVIKPISIAGGFYGE--EPLHT------PIVVTSTPAVTPG-
FOS_HUMAN FDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVV
FOSL1_HUMAN ------PAPCRPVPCISLSPGPVLEPEALHTPT----------------LMTTPSLTP--
XBP1_HUMAN LQQVQAQLSPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQR
Consensus
Prim.cons. LQQTRPPSS2LPPAIQ23S33PPLQG2S3FSV2EQVP3SV4S4423PM22H5TP2S2P52
850 860 870 880 890
| | | | |
AP1_HUMAN -----------------------------------------------------
JUND_HUMAN -----------------------------------------------------
JUNB_HUMAN -----------------------------------------------------
MAFB_HUMAN -----------------------------------------------------
MAF_HUMAN -----------------------------------------------------
ATF2_HUMAN SQIVMAPSSQSQPSGS-------------------------------------
ATF7_HUMAN SHVIMTPQSQSAGR---------------------------------------
CREB5_HUMAN -----------------------------------------------------
ATF6A_HUMAN LRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ-------------------
ATF6B_HUMAN LRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP---------------
BACH1_HUMAN ARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE---------
BACH2_HUMAN TSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT--
NF2L1_HUMAN -----------------------------------------------------
NF2L3_HUMAN -----------------------------------------------------
NF2L2_HUMAN -----------------------------------------------------
NFE2_HUMAN -----------------------------------------------------
ATF1_HUMAN -----------------------------------------------------
CREB1_HUMAN -----------------------------------------------------
CREM_HUMAN -----------------------------------------------------
CEBPA_HUMAN -----------------------------------------------------
CEBPB_HUMAN -----------------------------------------------------
CEBPE_HUMAN -----------------------------------------------------
CEBPD_HUMAN -----------------------------------------------------
DBP_HUMAN -----------------------------------------------------
HLF_HUMAN -----------------------------------------------------
TEF_HUMAN -----------------------------------------------------
ATF4_HUMAN -----------------------------------------------------
ATF5_HUMAN -----------------------------------------------------
NRL_HUMAN -----------------------------------------------------
DDIT3_HUMAN -----------------------------------------------------
ZHANG_HUMAN FCSACARKASSSLKM--------------------------------------
ATF3_HUMAN -----------------------------------------------------
BATF_HUMAN -----------------------------------------------------
CEBPG_HUMAN -----------------------------------------------------
MAFF_HUMAN -----------------------------------------------------
MAFG_HUMAN -----------------------------------------------------
MAFK_HUMAN -----------------------------------------------------
CREB3_HUMAN PSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG
FOSB_HUMAN -------SYTSSFVLTCPEVSAF-----AGAQRTSG-SDQPSDPLNSPSLLAL
FOSL2_HUMAN --TSNLVFTYPSVLEQESPASPSESCSKAHRRSSSS-GDQSSDSLNSPTLLAL
FOS_HUMAN TCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSS-NEPSSDSLSSPTLLAL
FOSL1_HUMAN --------FTPSLVFTYP--STPEPCASAHRKSSSSSGDPSSDPLGSPTLLAL
XBP1_HUMAN STQKDPVPYQPPFLCQWGRHQPSWKPLMN------------------------
Consensus
Prim.cons. SR2Q24PQ22SSF2F22PPASA22SC3AAHR242SST2D3SSDSLNSPTLLAL
PREDATOR parameters
Secondary structure data
Return
SOPM parameters
Number of conformational states
Similarity threshold :
Window width :
Return
SOPMA parameters
Number of conformational states
Similarity threshold :
Window width :
Return